"The only part of DIO that was left after he turned to dust. It moves around seemingly with a mind of its own..." —Narrator
DIO's Bone is a needed item to finish some specific quests for stands such as C-Moon, Made in Heaven or The World : Over Heaven. It can be either obtained by chests with a low chance or by killing the DIO boss. Its first appearance in the manga was on the 6th part of the JoJo Manga series Stone Ocean.